| Saumithraसौमीत्रा | Lord Lakshman son of Sumitra) |
| Sauvarसौवार | Belonging to sound, A musical note |
| Savantसवंत | A learned and wise scholar. |
| Savya Sachiसाव्य-साची | Another name of Arjun, Ambidextrous |
| Savyamoonthसवयमूनतः | Savyamoonth comes from An Indian word meaning, Defender of people |
| Savyashacheeसव्यसाची | Ambidextrous while shooting |
| Sayshanthसयशांत | Avatar of Lord Vishnu, Good peace |
| Selva Kumarसेलवा कुमार | A wealthy and prosperous young prince. |
| Selvanathnसेल्वनाथं | Selvanathn means 'Gift of the Lord' or 'Divine Gift' in Sanskrit, a combination of Selva (Lord) and Nathn (Gift). |
| Selvianसेल्वियन | Of or pertaining to Selvians, a people or tribe, possibly from the Latin 'selvus' meaning wild or savage. |
| Senaanyसेनानी | One of the kauravas |
| Senthil Kumarसेंतील कुमार | Lord Murugan, Always youth |
| Serasसेरस | Derived from the Latin word 'serere,' meaning to sow or plant, often associated with fertility. |
| Seshanandसेशानंद | Lord Vishnu, Beloved of sesh |
| Sesuसेसु | Snake, Venkateswara |
| Sethu Lakshmiसेतु लक्ष्मी | Goddess Lakshmi, Worth |
| Setukruteसेतुकृते | Builder of the bridge over ocean |
| Sewinसेवीन | Sewin is a Welsh name meaning 'little river' or 'stream', derived from the Old Welsh word 'sawyn'. |
| Shaantivशांतिव | One who is peaceful and calm in nature. |
| Shaastशास्त | Ruler, One who commands |
| Shaastiशास्ती | Command, Royal authority, Hymn, Lord Murugan, Another name for Durga |
| Shabastशाबस्त | Armoured, Protected |
| Shadanananशादनानन | Lord Subramanyan |
| Shagdavशाग्दव | Shagdav is a Mongolian name meaning 'bringer of good fortune' or 'auspicious one'. |
| Shailajशैलज | Daughter of the mountains |
| Shaininशैनीन | Peaceful, Restrained |
| Shajaneeshशाजनीश | Shajaneesh is a Sanskrit name meaning 'Victory of the Lord' or 'Triumphant Lord'. |
| Shajunanशाजुनान | Shajunan is a variant of the name Shahjahan, meaning 'world conqueror' or 'conqueror of the world'. |
| Shakithशकित | Shakith is a variant of Shakitha, meaning 'blessed' or 'fortunate' in Sanskrit, derived from the word 'shak' meaning 'good fortune'. |
| Shakthidharशक्तीधर | Lord Shiva, The Lord Subramanian |
| Shakunthशाकुन्त | Derived from a bird, meaning auspicious. |
| Shakyaशक्य | Lord Buddha, Energy circle or a form of chakra |
| Shalivahanशालिवाहन | Name of a famous king |
| Hari Priyaहरीप्रिया | Goddess Lakshmi, Beloved of Hari |
| Shamathशामत | Quiet, Tranquillity, A counseller, Residing in peace, Peaceful, Calm |
| Shamenशामेन | Holy Man, Happy, Auspicious, Security, Wealthy |
| Shamijithशमिजीत | Shamijith means 'peaceful victory' or 'victory of peace' in Malayalam, a language spoken in southern India. |
| Shammadशाम्मद | One who has conquered his ego |
| Shampakशम्पक | Created by thunderbolts, Brilliant |
| Shamvatशंवत | Auspicious, Wealthy |